A very common place for a vacuum leak on the E55’s is that port on the rear of the supercharger with a strange multi-piece plug in it. I assume that port is used for the brake booster on cars that don’t have the SBC system, but it is beyond me why the engineers at Mercedes-Benz decided to make a three-part plug to fill it instead of using a simple rubber plug. This is especially strange since there is an existing Mercedes part that seems to work perfectly.
Simple Plug for Supercharger Vacuum Port

